One year overall survival of wilms tumor cases and its predictors, among children diagnosed at a teaching hospital in South Western Uganda:
Date
2023-03-02Author
Eddymond, Ekuk
Charles Newton, Odongo
Leevan, Tibaijuka
Felix, Oyania
Walufu Ivan, Egesa
Felix, Bongomin
Raymond, Atwiine
Moses, Acan
Martin, Situma
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Abstract
Background Wilms tumor (WT) is the second most common solid tumor in Africa with both low overall survival (OS)
and event-free survival (EFS) rates. However, no known factors are predicting this poor overall survival.
Objective The study was to determine the one-year overall survival of WT cases and its predictors among children
diagnosed in the pediatric oncology and surgical units of Mbarara regional referral hospital (MRRH), western Uganda.
Methodology Children’s treatment charts and fles diagnosed and managed for WT were retrospectively followed
up for the period between January 2017 to January 2021. Charts of children with histologically confrmed diagnoses
were reviewed for demographics, clinical and histological characteristics, as well as treatment modalities.
Results One-year overall survival was found to be 59.3% (95% CI: 40.7–73.3), with tumor size greater than 15 cm (p
0.021) and unfavorable WT type (p 0.012) being the predominant predictors.
Conclusion Overall survival (OS) of WT at MRRH was found to be 59.3%, and predictive factors noted were unfavora ble histology and tumor size greater than 115 cm.