dc.contributor.author | Emmanuel D, Morgan | |
dc.contributor.author | Tonny, Okecha | |
dc.contributor.author | James J., Yahaya | |
dc.contributor.author | Emmanuel, Othieno | |
dc.date.accessioned | 2023-07-19T12:26:59Z | |
dc.date.available | 2023-07-19T12:26:59Z | |
dc.date.issued | 2022-05-20 | |
dc.identifier.citation | Morgan, E. D., Okecha, T., Yahaya, J. J., & Othieno, E. (2022). Malignant mixed mullerian tumor: A case report about a uterine Tumor's case. International Journal of Surgery Open, 43, 100493. | en_US |
dc.identifier.uri | https://ir.sun.ac.ug//handle/123456789/62 | |
dc.description.abstract | Abstract:
Introduction: Malignant mixed Mullerian tumor (MMMT) is an exceedingly rare and aggressive tumor which
occurs predominantly in postmenopausal women though it has been reported rarely in premenopausal women.
Case presentation: A 54-year old nulliparous postmenopausal female presented with a 3-month history of vaginal
bleeding, mild lower abdominal pain and weight loss. Ultrasound revealed markedly enlarged uterus with a
hyper-echoic solid and cystic mass and a right adnexal complex mass. Total abdominal hysterectomy and
bilateral salpingioopherectomy were done. Histopathological features were consistent with MMMT. The patient
is currently stable after 6 cycles of adjuvant chemotherapy which consisted of paclitaxel and carboplatin.
Clinical discussion: MMMT of the uterus is rare, high-grade neoplasms comprising only 1–2% of uterine cancers
and 3–5% of all uterine malignancies. This tumor may arise in the ovaries, fallopian tubes and vagina. Histologically,
MMMT is a biphasic tumor composed of both epithelial (carcinoma) elements and mesenchymal
(sarcoma) elements; though, which component is responsible for the tumor’s aggressive biological behavior
remains undetermined.
Conclusion: MMMT is a rare and aggressive tumor which is commonly seen in postmenopausal women with high
rate of recurrence therefore, Radical surgery and close follow-up is mandatory since the role of chemoradiotherapy
remains unclear in the management of patients with this tumor. Both stage of the tumor and
myometrial invasion are considered as potential prognostic factors. | en_US |
dc.description.sponsorship | No Funding | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Ltd on behalf of Surgical Associates Ltd. | en_US |
dc.subject | Malignant mixed mullerian tumor Carcinosarcoma | en_US |
dc.title | Malignant mixed mullerian tumor: | en_US |
dc.title.alternative | A case report about a uterine Tumor’s case | en_US |
dc.type | Article | en_US |